Thupchen Gonpa was built during the period of the third king of Lo, Tashi Gon in late 15th century CE. In its heyday, Thupchen Gonpa was the major center of all religious activities in Lo-Manthang. The entrance room (Sgo-Mchog) displays four larger-than-life images of the four directions (Gyal-Chen Shi), all enshrined upon raised platforms.
Its main hall, called "Dhunkhang", contains wooded pillars and a ceiling rafted which in engraved with sacred mantras. The walls and ceiling of the Dhunkhang are painted with ornate images of the Buddhas and bodhisattvas in gold, silver and bright colors. They are seated with their hands in various gestures (mudras). The hall also houses three earthen images of Avalokitsevara (Chenrezig), Manjushri (Jampayang) and Padmasambhava (Guru Rinpoche). The image of the Great Buddha (Thupchen) is made of copper an polished in gold, and he is in seated posture.